$750.00 – $14,100.00

Pseudoviruses for Human Papillomaviridae

Name: Pseudoviruses for Human Papillomaviridae
SKU: 5691
Availability: InStock

Serotype

Reporter Gene

Size and Price

Clear

Quantity

In stock

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Serotype	HPV-6, HPV-11, HPV-16, HPV-18, HPV-31, HPV-33, HPV-35, HPV-39, HPV-45, HPV-51, HPV-52, HPV-56, HPV-58, HPV-59, HPV-68a
Reporter Gene	Firefly Luciferase, GFP, RFP
Size and Price	5 x 200 µL ~20 wells/96 well plate, 10 x 200 µL ~40 wells/96 well plate, 5 mL ~100 wells/96 well plate, 10 mL ~200 wells/96 well plate, 20 mL ~400 wells/96 well plate, 5 x 100 µL (Concentrated Only)

SKU:N/A Category:Pseudovirus

Product Description

Human Papillomaviridae Pseudoviruses

Built-to-order pseudovirus for HPV with the L1 and L2 proteins.

Applications

HPV pseudovirus transduction of target cells for viral entry and functional studies
Rapid Anti-HPV drug screening
Rapid Anti-HPV neutralizing antibody screening

A novel rapid pseudovirus for Human Papillomavirus and other Papillomaviridae viruses is now available at Virongy. These particles are pseudoviruses assembled from the structural proteins of the Human Papillomavirus: L1 and L2 proteins. These particles encapsulate a linear DNA viral vector for reporter gene expression. The pseudoviruses are single-cycle with a linear DNA genome for robust reporter gene generation to quantify neutralizing antibodies and entry-inhibiting drugs. These pseudoviruses are BSL-2 safe and ready to use for studying viral entry. Furthermore, we assist our customers in constructing HPV pseudoviruses with custom capsids at any scale.

For inquiries, please reach out to us via email: info@virongy.com

To enhance your pseudovirus entry, inquire about receiving a complimentary sample of our proprietary Infectin, which significantly enhances productive viral infection in various host cells, thereby boosting the viral infection rate by 3- to 20-fold.

Background:

Human Papillomavirus (HPV) is a small, double-stranded DNA virus belonging to the Papillomaviridae family. It primarily infects epithelial cells in the skin and mucous membranes. HPV is highly diverse, with over 200 identified genotypes. The virus’s life cycle is intimately linked with the differentiation of infected epithelial cells. Upon infection, the viral DNA is delivered to the nucleus of the host cell. The virus then utilizes the cellular machinery to replicate its DNA and generate new viral particles.

Certain high-risk HPV types, notably HPV-16 and HPV-18, are associated with the development of cancers, particularly cervical cancer. These types encode oncoproteins (E6 and E7) that interfere with the host cell cycle, potentially leading to uncontrolled cell growth and malignancy. HPV is primarily transmitted through direct skin-to-skin contact, with sexual activity being the most common mode of transmission. It can also be transmitted from mother to child during childbirth. HPV alpha-pseudovirus HPV alpha-pseudovirus