Virongy Biosciences develops cutting-edge technologies in virology and viral vectors to accelerate scientific discovery, clinical diagnostics, and disease treatment.

Model of HIV exploitation of actin dynamics to overcome the cortical actin barrier. Cortical actin (green staining, F-actin) in blood CD4 T cells remains relatively static in the absence of chemotactic signaling. Binding of viral envelope protein gp120 to CXCR4/CCR5 triggers a transient course of actin polymerization and depolymerization, through the activation of the cofilin/Arp2/3 pathways, to facilitate viral entry and post-entry nuclear migration.

The HIV Rev-dependent reporter cells licensed and commercialized by Virongy represent a major advancement in the development of HIV indicator cells (Wu et al., 2007). This new reporter system differs dramatically from the common LTR-based reporter cells, which rely solely on the HIV promoter, the long terminal repeat (LTR), to drive reporter expression. 

The HIV Rev-dependent reporter platform are the best HIV-indicators on the market, with the highest specificity and accuracy in quantifying HIV infection. They can be used for anti-HIV drug screening, anti-HIV antibody screening, and the screening of anti-HIV compounds targeting host restriction or dependency factors (Wu et al., 2007, Curr HIV Res. 5:394).

Quantification of anti-HIV neutralizing antibody B12 with Rev-A3R5-GFP reporter cells

The Exo-HEK293T enhances the production of exosomes and microvesicles, providing customers with consistent production of quality EVs that can be customized to meet individual research needs. Combine with our high-efficiency transfection reagent, Transfectin, for simple and rapid production of exosomes and EVs.

Key Features:

  • High exosome and microvesicle production rate
  • Customizable to fit your research needs
  • Consistent production for long-term use

    ExoMaxed Expression of CD9 

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Yi, F., Guo, J., Dabbagh, D., Spear, M., He, S., Kehn-Hall, K., Fontenot, J., Yin, Y., Bibian, M., Park, C.M., et al. (2017). Discovery of Novel Small Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. J Virol. 91:e02418-16.

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