Virongy Biosciences develops cutting-edge technologies in virology and viral vectors to accelerate scientific discovery, clinical diagnostics, and disease treatment.
Virongy's Key Technologies
Hybrid alpha-pseudoviruses are a newly developed pseudovirus platform for rapidly screening viral entry inhibitors. They consist of a virus-like particle (VLP) that encapsulates an alphavirus-derived RNA genome for rapid report expression (luciferase or GFP) in target cells (Hetrick et al., 2022). Ha-CoV-2 represents a major technology advancement in the development of SARS-CoV-2 pseudoviruses, and serves as platforms for rapid and robust quantification of neutralizing antibodies, viral mutants, and antiviral drugs (Dabbagh et al., 2021; He et al., 2021).
The HIV Rev-dependent reporter cells licensed and commercialized by Virongy represent a major advancement in the development of HIV indicator cells (Wu et al., 2007). This new reporter system differs dramatically from the common LTR-based reporter cells, which rely solely on the HIV promoter, the long terminal repeat (LTR), to drive reporter expression.
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